| First Author | Behr FM | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 400 | PubMed ID | 30899267 |
| Mgi Jnum | J:294448 | Mgi Id | MGI:6456413 |
| Doi | 10.3389/fimmu.2019.00400 | Citation | Behr FM, et al. (2019) Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8(+) T Cells in the Lungs. Front Immunol 10:400 |
| abstractText | Tissue-resident memory CD8(+) T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8(+) TRM cells within the skin and the small intestine are long-lived and maintained independently of circulating memory CD8(+) T cells. In contrast to CD8(+) TRM cells at these sites, CD8(+) TRM cells that arise after influenza virus infection within the lungs display high turnover and require constant recruitment from the circulating memory pool for long-term persistence. The distinct characteristics of CD8(+) TRM cell maintenance within the lungs may suggest a unique program of transcriptional regulation of influenza-specific CD8(+) TRM cells. We have previously demonstrated that the transcription factors Hobit and Blimp-1 are essential for the formation of CD8(+) TRM cells across several tissues, including skin, liver, kidneys, and the small intestine. Here, we addressed the roles of Hobit and Blimp-1 in CD8(+) TRM cell differentiation in the lungs after influenza infection using mice deficient for these transcription factors. Hobit was not required for the formation of influenza-specific CD8(+) TRM cells in the lungs. In contrast, Blimp-1 was essential for the differentiation of lung CD8(+) TRM cells and inhibited the differentiation of central memory CD8(+) T (TCM) cells. We conclude that Blimp-1 rather than Hobit mediates the formation of CD8(+) TRM cells in the lungs, potentially through control of the lineage choice between TCM and TRM cells during the differentiation of influenza-specific CD8(+) T cells. |
