| First Author | Hung LY | Year | 2021 |
| Journal | Am J Pathol | Volume | 191 |
| Issue | 2 | Pages | 266-273 |
| PubMed ID | 33245913 | Mgi Jnum | J:304384 |
| Mgi Id | MGI:6510437 | Doi | 10.1016/j.ajpath.2020.11.004 |
| Citation | Hung LY, et al. (2021) Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium-Induced Colitis. Am J Pathol 191(2):266-273 |
| abstractText | IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate inflammation. Whether IL-33 serves a pathogenic or protective role during inflammatory bowel disease is controversial. Herein, two different strains of cell-specific conditionally deficient mice were used to compare the role of myeloid- versus intestinal epithelial cell-derived IL-33 during dextran sodium sulfate-induced colitis. Data show that loss of CD11c-restricted IL-33 exacerbated tissue pathology, coinciding with increased tissue Il6 levels and loss of intestinal forkhead box p3(+) regulatory T cells. Surprisingly, the lack of intestinal epithelial cell-derived IL-33 had no impact on disease severity or tissue recovery. Thus, we show that myeloid-derived IL-33 functionally restrains colitic disease, whereas intestinal epithelial cell-derived IL-33 is dispensable. |
