| First Author | Cai J | Year | 2010 |
| Journal | Genes Dev | Volume | 24 |
| Issue | 21 | Pages | 2383-8 |
| PubMed ID | 21041407 | Mgi Jnum | J:165471 |
| Mgi Id | MGI:4837547 | Doi | 10.1101/gad.1978810 |
| Citation | Cai J, et al. (2010) The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 24(21):2383-8 |
| abstractText | Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely unknown. Here we address this issue using a dextran sodium sulfate (DSS)-induced colonic regeneration model. We find that regenerating crypts express elevated Yes-associated protein (YAP) levels. Inactivation of YAP causes no obvious intestinal defects under normal homeostasis, but severely impairs DSS-induced intestinal regeneration. Conversely, hyperactivation of YAP results in widespread early-onset polyp formation following DSS treatment. Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program. |
