| First Author | Xu C | Year | 2014 |
| Journal | IUBMB Life | Volume | 66 |
| Issue | 10 | Pages | 694-703 |
| PubMed ID | 25355554 | Mgi Jnum | J:232536 |
| Mgi Id | MGI:5779491 | Doi | 10.1002/iub.1319 |
| Citation | Xu C, et al. (2014) Regulation of sonic hedgehog expression by integrin beta1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life 66(10):694-703 |
| abstractText | We previously found that conditional deletion of integrin beta1 in intestinal epithelium of mice caused early postnatal lethality and intestinal phenotypic changes including excessive proliferation and defective differentiation of intestinal epithelium due to loss of Hedgehog expression. Here, we link these defects to the Hedgehog (Hh) signaling pathway and show that loss of integrin beta1 leads to excessive phosphorylation of MEK-1 and increased expression of ErbB receptors, including the epidermal growth factor receptor (EGFR). We show that increased EGFR signaling attenuates Hh abundance and that an EGFR inhibitor rescues conditional beta1 integrin null pups from postnatal lethality. These studies link the loss of Hh expression in the intestinal epithelium of integrin beta1-deficient mice to excessive EGFR/MAPK signaling, and identify a unique mechanism for crosstalk between stromal and epithelial signaling pathways that is critical for intestinal epithelial differentiation and function. |
