| Primary Identifier | MGI:2448760 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(CD2-MYC)1Jcn |
| Strain of Origin | (C57BL/6J x CBA/Ca)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Two transgenic lines designated the 800 series and 900 series was established. Animals of the 800 series carry 13 copies of the integrated transgene and exhibit 22% incidence of thymic lymphomas. Animals of the 900 series carry 3 copies of the integrated transgene and exhibit 3% incidence of thymic lymphomas. |
| molecularNote | The transgene consists of a human MYC genomic sequence and a 5.5 kb fragment containing the human CD2 dominant control region to drive expression in T lymphocytes. Northern blot analysis using a human MYC exon 1 probe revealed transgene expression in all thymic tumors, but not in healthy tissues. |
