| First Author | Revenkova E | Year | 2010 |
| Journal | Curr Biol | Volume | 20 |
| Issue | 17 | Pages | 1529-33 |
| PubMed ID | 20817531 | Mgi Jnum | J:166776 |
| Mgi Id | MGI:4849595 | Doi | 10.1016/j.cub.2010.08.024 |
| Citation | Revenkova E, et al. (2010) Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy. Curr Biol 20(17):1529-33 |
| abstractText | To ensure correct meiotic chromosome segregation, sister chromatid cohesion (SCC) needs to be maintained from its establishment in prophase I oocytes before birth until continuation of meiosis into metaphase II upon oocyte maturation in the adult. Aging human oocytes suffer a steep increase in chromosome missegregation and aneuploidy, which may be caused by loss of SCC through slow deterioration of cohesin [1-3]. This hypothesis assumes that cohesin expression in embryonic oocytes is sufficient to provide adequate long-term SCC. With increasing age, mouse oocytes deficient in the meiosis-specific cohesin SMC1beta massively lose SCC and chiasmata [3, 4]. To test the deterioration hypothesis, we specifically and highly efficiently inactivated the mouse Smc1beta gene at the primordial follicle stage shortly after birth, when oocytes had just entered meiosis I dictyate arrest. In the adult, however, irrespective of oocyte age, chiasma positions and SCC are normal. Frequency and size of litters prove full fertility even in aged females. Thus, SMC1beta cohesin needs only be expressed during prophase I prior to the primordial follicle stage to ensure SCC up to advanced age of mice. |
