| Primary Identifier | MGI:2449175 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Dkc1 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A hypomorphic allele was generated by insertion of a neo cassette 3' to the wild-type locus. The targeting construct carries a duplication of exons 10-15 of Dkc1, with the neo cassette inserted into exon 10. Northern blot analysis of embryonic fibroblasts derived from mutant mice show a 4-fold and 2-fold decrease in gene expression in hemizygous male and heterozygous females, respectively. |
