| Primary Identifier | MGI:2449909 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Ret |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant animals lacked kidneys and enteric neurons and died shortly after birth. |
| molecularNote | The gene was disrupted by insertion of an EGFP-derived cassette and a floxed neo cassette into exon 1 via homologous recombination. The floxed neo cassette was removed by mating mutant animals to cre deleter strain TgN(ACTB-cre)2Mrt. Immunohistochemical analysis of homozygous mutant newborns confirmed the absence of gene expression in spinal motorneurons. |
