| First Author | Sabaté San José A | Year | 2024 |
| Journal | Front Cell Neurosci | Volume | 18 |
| Pages | 1337621 | PubMed ID | 38405598 |
| Mgi Jnum | J:345896 | Mgi Id | MGI:7608777 |
| Doi | 10.3389/fncel.2024.1337621 | Citation | Sabate San Jose A, et al. (2024) Absence of meningeal mast cells in the Mitf mutant mouse. Front Cell Neurosci 18:1337621 |
| abstractText | Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges. |
