| First Author | Tsuyama J | Year | 2015 |
| Journal | Stem Cell Reports | Volume | 5 |
| Issue | 3 | Pages | 365-77 |
| PubMed ID | 26212661 | Mgi Jnum | J:310005 |
| Mgi Id | MGI:6759075 | Doi | 10.1016/j.stemcr.2015.06.006 |
| Citation | Tsuyama J, et al. (2015) MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells. Stem Cell Reports 5(3):365-77 |
| abstractText | Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS. |
