| First Author | Wang CZ | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31120418 | Mgi Jnum | J:352068 |
| Mgi Id | MGI:6316768 | Doi | 10.7554/eLife.44649 |
| Citation | Wang CZ, et al. (2019) Early-generated interneurons regulate neuronal circuit formation during early postnatal development. Elife 8 |
| abstractText | A small subset of interneurons that are generated earliest as pioneer neurons are the first cohort of neurons that enter the neocortex. However, it remains largely unclear whether these early-generated interneurons (EGIns) predominantly regulate neocortical circuit formation. Using inducible genetic fate mapping to selectively label EGIns and pseudo-random interneurons (pRIns), we found that EGIns exhibited more mature electrophysiological and morphological properties and higher synaptic connectivity than pRIns in the somatosensory cortex at early postnatal stages. In addition, when stimulating one cell, the proportion of EGIns that influence spontaneous network synchronization is significantly higher than that of pRIns. Importantly, toxin-mediated ablation of EGIns after birth significantly reduce spontaneous network synchronization and decrease inhibitory synaptic formation during the first postnatal week. These results suggest that EGIns can shape developing networks and may contribute to the re fi nement of neuronal connectivity before the establishment of the adult neuronal circuit. |
