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Publication : Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

First Author  De Schepper S Year  2018
Journal  Cell Volume  175
Issue  2 Pages  400-415.e13
PubMed ID  30173915 Mgi Jnum  J:267382
Mgi Id  MGI:6259199 Doi  10.1016/j.cell.2018.07.048
Citation  De Schepper S, et al. (2018) Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. Cell 175(2):400-415.e13
abstractText  Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissue-supportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer's patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology.
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