| First Author | Kurschus FC | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 12 | Pages | 3336-46 |
| PubMed ID | 21110317 | Mgi Jnum | J:174664 |
| Mgi Id | MGI:5140295 | Doi | 10.1002/eji.201040755 |
| Citation | Kurschus FC, et al. (2010) Genetic proof for the transient nature of the Th17 phenotype. Eur J Immunol 40(12):3336-46 |
| abstractText | IL-17-producing CD4(+) T cells (Th17) have been classified as a new T helper cell subset. Using an IL-17 fate mapping mouse strain, which genetically fixes the memory of IL-17 expression, we demonstrate that IL-17A/F-expressing T helper cells generated either in vitro or in vivo are not a stable T-cell subset. Upon adoptive transfer of IL-17F-reporter-positive Th17 cells to RAG-deficient or WT animals, encephalitogenic Th17 cells partially lose IL-17 expression and upregulate IFN-gamma. Additionally, we show that Th1 cells can convert in vivo to IL-17A/IFN-gamma-coexpressing cells in the mesenteric lymph nodes (mLN). Our data classify IL-17A and IL-17F as cytokines produced transiently in response to the local microenvironment, thus showing that IL-17 expression does not define an end-stage T helper cell subset. |
