| First Author | Larraufie P | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 6 | Pages | 1399-1408.e6 |
| PubMed ID | 30726726 | Mgi Jnum | J:300929 |
| Mgi Id | MGI:6489116 | Doi | 10.1016/j.celrep.2019.01.047 |
| Citation | Larraufie P, et al. (2019) Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Rep 26(6):1399-1408.e6 |
| abstractText | Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely reported, but the importance of GLP-1 in post-bariatric physiology remains debated. Here, we show that GLP-1 is a major driver of insulin secretion after bariatric surgery, as demonstrated by blocking GLP-1 receptors (GLP1Rs) post-gastrectomy in lean humans using Exendin-9 or in mice using an anti-GLP1R antibody. Transcriptomics and peptidomics analyses revealed that human and mouse enteroendocrine cells were unaltered post-surgery; instead, we found that elevated plasma GLP-1 and PYY correlated with increased nutrient delivery to the distal gut in mice. We conclude that increased GLP-1 secretion after bariatric surgery arises from rapid nutrient delivery to the distal gut and is a key driver of enhanced insulin secretion. |
