| First Author | Anderson AG | Year | 2020 |
| Journal | Cell Rep | Volume | 30 |
| Issue | 9 | Pages | 3051-3066.e7 |
| PubMed ID | 32130906 | Mgi Jnum | J:288270 |
| Mgi Id | MGI:6416704 | Doi | 10.1016/j.celrep.2020.02.030 |
| Citation | Anderson AG, et al. (2020) Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development. Cell Rep 30(9):3051-3066.e7 |
| abstractText | The striatum is a critical forebrain structure integrating cognitive, sensory, and motor information from diverse brain regions into meaningful behavioral output. However, the transcriptional mechanisms underlying striatal development at single-cell resolution remain unknown. Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion. We also identify Foxp1-regulated target genes within distinct cell types and connect these molecular changes to functional and behavioral deficits relevant to phenotypes described in patients with FOXP1 loss-of-function mutations. Using this approach, we could also examine the non-cell-autonomous effects produced by disrupting one cell type and the molecular compensation that occurs in other populations. These data reveal the cell-type-specific transcriptional mechanisms regulated by Foxp1 that underlie distinct features of striatal circuitry. |
