| First Author | Porcheri C | Year | 2014 |
| Journal | J Neurosci | Volume | 34 |
| Issue | 15 | Pages | 5222-32 |
| PubMed ID | 24719101 | Mgi Jnum | J:208112 |
| Mgi Id | MGI:5561134 | Doi | 10.1523/JNEUROSCI.4928-13.2014 |
| Citation | Porcheri C, et al. (2014) Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. J Neurosci 34(15):5222-32 |
| abstractText | Controlling neural stem and progenitor cell (NSPC) proliferation is critical to maintain neurogenesis in the mammalian brain throughout life. However, it remains poorly understood how niche-derived cues such as beta1-integrin-mediated signaling are translated into NSPC-intrinsic molecular changes to regulate NSPC activity. Here we show that genetic deletion of integrin-linked kinase (ILK) increases NSPC proliferation through PINCH1/2-dependent enhancement of c-Jun N-terminal protein kinase activity in both neurogenic regions of the adult mouse brain. This effect downstream of ILK signaling is mediated through loss of Ras suppressor unit-1 (RSU-1), as virus-based reconstitution of RSU-1 expression rescued the ILK-dependent effects on NSPC proliferation. Thus, we here identified an intracellular signaling cascade linking extrinsic integrin-mediated signaling to NSPC proliferation and characterized a novel mechanism that regulates NSPC activity in the adult mammalian brain. |
