| First Author | Alderman PJ | Year | 2024 |
| Journal | Neuron | Volume | 112 |
| Issue | 4 | Pages | 574-592.e10 |
| PubMed ID | 38086370 | Mgi Jnum | J:350469 |
| Mgi Id | MGI:7663318 | Doi | 10.1016/j.neuron.2023.11.010 |
| Citation | Alderman PJ, et al. (2024) Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron 112(4):574-592.e10 |
| abstractText | The human amygdala paralaminar nucleus (PL) contains many immature excitatory neurons that undergo prolonged maturation from birth to adulthood. We describe a previously unidentified homologous PL region in mice that contains immature excitatory neurons and has previously been considered part of the amygdala intercalated cell clusters or ventral endopiriform cortex. Mouse PL neurons are born embryonically, not from postnatal neurogenesis, despite a subset retaining immature molecular and morphological features in adults. During juvenile-adolescent ages (P21-P35), the majority of PL neurons undergo molecular, structural, and physiological maturation, and a subset of excitatory PL neurons migrate into the adjacent endopiriform cortex. Alongside these changes, PL neurons develop responses to aversive and appetitive olfactory stimuli. The presence of this homologous region in both humans and mice points to the significance of this conserved mechanism of neuronal maturation and migration during adolescence, a key time period for amygdala circuit maturation and related behavioral changes. |
