| First Author | Hikida M | Year | 2003 |
| Journal | J Exp Med | Volume | 198 |
| Issue | 4 | Pages | 581-9 |
| PubMed ID | 12913095 | Mgi Jnum | J:85103 |
| Mgi Id | MGI:2671728 | Doi | 10.1084/jem.20030280 |
| Citation | Hikida M, et al. (2003) Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development. J Exp Med 198(4):581-9 |
| abstractText | Two signaling pathways known to be essential for progression from immature to mature B cells are BAFF receptor (BAFF-R) and the B cell receptor (BCR). Here, we first show that phospholipase C (PLC)-gamma2 is required for a BAFF-R-mediated survival signal. Then, we have examined the question of whether the reduced number of mature B cells in PLC-gamma2-/- mice is caused by a defect in either BCR or BAFF-R signaling. We find that a PLC-gamma2 SH2 mutant, which inhibits coupling between BCR and PLC-gamma2, fails to restore B cell maturation, despite supporting BAFF-dependent survival. Therefore, our data suggest that the BAFF-R-mediated survival signal, provided by PLC-gamma2, is not sufficient to promote B cell maturation, and that, in addition, activation of PLC-gamma2 by BCR is required for B cell development. |
