| First Author | Webb LM | Year | 2016 |
| Journal | J Immunol | Volume | 196 |
| Issue | 1 | Pages | 207-16 |
| PubMed ID | 26621859 | Mgi Jnum | J:240006 |
| Mgi Id | MGI:5882183 | Doi | 10.4049/jimmunol.1501582 |
| Citation | Webb LM, et al. (2016) GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo. J Immunol 196(1):207-16 |
| abstractText | An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell-mediated diseases. |
