| First Author | Chopra S | Year | 2019 |
| Journal | Science | Volume | 365 |
| Issue | 6450 | PubMed ID | 31320508 |
| Mgi Jnum | J:277602 | Mgi Id | MGI:6336201 |
| Doi | 10.1126/science.aau6499 | Citation | Chopra S, et al. (2019) IRE1alpha-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science 365(6450) |
| abstractText | Inositol-requiring enzyme 1[alpha] (IRE1[alpha])-X-box binding protein spliced (XBP1) signaling maintains endoplasmic reticulum (ER) homeostasis while controlling immunometabolic processes. Yet, the physiological consequences of IRE1alpha-XBP1 activation in leukocytes remain unexplored. We found that induction of prostaglandin-endoperoxide synthase 2 (Ptgs2/Cox-2) and prostaglandin E synthase (Ptges/mPGES-1) was compromised in IRE1alpha-deficient myeloid cells undergoing ER stress or stimulated through pattern recognition receptors. Inducible biosynthesis of prostaglandins, including the pro-algesic mediator prostaglandin E2 (PGE2), was decreased in myeloid cells that lack IRE1alpha or XBP1 but not other ER stress sensors. Functional XBP1 transactivated the human PTGS2 and PTGES genes to enable optimal PGE2 production. Mice that lack IRE1alpha-XBP1 in leukocytes, or that were treated with IRE1alpha inhibitors, demonstrated reduced pain behaviors in PGE2-dependent models of pain. Thus, IRE1alpha-XBP1 is a mediator of prostaglandin biosynthesis and a potential target to control pain. |
