| First Author | Plasari G | Year | 2010 |
| Journal | J Biol Chem | Volume | 285 |
| Issue | 44 | Pages | 34115-25 |
| PubMed ID | 20729551 | Mgi Jnum | J:166785 |
| Mgi Id | MGI:4849604 | Doi | 10.1074/jbc.M110.120659 |
| Citation | Plasari G, et al. (2010) Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling. J Biol Chem 285(44):34115-25 |
| abstractText | Skin appendages such as teeth and hair share several common signaling pathways. The nuclear factor I C (NFI-C) transcription factor has been implicated in tooth development, but a potential role in hair growth had not been assessed. In this study we found that NFI-C regulates the onset of the hair growth cycle. NFI-C(-/-) mice were delayed in the transition from the telogen to anagen phase of the hair follicle cycle after either experimental depilation or spontaneous hair loss. Lack of NFI-C resulted in delayed induction of the sonic hedgehog, Wnt5a, and Lef1 gene expression, which are key regulators of the hair follicle growth initiation. NFI-C(-/-) mice also showed elevated levels of transforming growth factor beta1 (TGF-beta1), an inhibitor of keratinocyte proliferation, and of the cell cycle inhibitor p21 at telogen. Reduced expression of Ki67, a marker of cell proliferation, was noted at the onset of anagen, indicating impaired activation of the hair progenitor cells. These findings implicate NFI-C in the repression of TGF-beta1 signaling during telogen stage, resulting in the delay of progenitor cell proliferation and hair follicle regeneration in NFI-C-deficient mice. Taken together with prior observations, these findings also designate NFI-C as a regulator of adult progenitor cell proliferation and of postnatal tissue growth or regeneration. |
