| First Author | Crowther RR | Year | 2022 |
| Journal | J Immunol | Volume | 208 |
| Issue | 4 | Pages | 793-798 |
| PubMed ID | 35101895 | Mgi Jnum | J:336971 |
| Mgi Id | MGI:7257960 | Doi | 10.4049/jimmunol.2100652 |
| Citation | Crowther RR, et al. (2022) Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4(+) T Cell Viability and Proliferation. J Immunol 208(4):793-798 |
| abstractText | Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synthesis pathway in immune cells; however, its role in APCs has yet to be uncovered. Using a coculture system with mycobacterial-specific CD4(+) T cells, we show APC L-ARG synthesis supported T cell viability and proliferation, and activated T cells contained APC-derived L-ARG. We hypothesize that APCs supply L-ARG to support T cell activation under nutrient-limiting conditions. This work expands the current model of APC-T cell interactions and provides insight into the effects of nutrient availability in immune cells. |
