| First Author | Banerjee I | Year | 2013 |
| Journal | Circ Res | Volume | 112 |
| Issue | 3 | Pages | e25-8 |
| PubMed ID | 23371905 | Mgi Jnum | J:213328 |
| Mgi Id | MGI:5584092 | Doi | 10.1161/CIRCRESAHA.111.300197 |
| Citation | Banerjee I, et al. (2013) Thymosin beta4 is not required for embryonic viability or vascular development. Circ Res 112(3):e25-8 |
| abstractText | RATIONALE: Rossdeutsch et al describe a requirement for thymosin beta4 (Tbeta4) in vascular development. Impaired mural cell migration, differentiation, partial embryonic lethality, and hemorrhaging were observed after analysis of 2 lines of mice, one of which was germline null for Tbeta4 and another in which Tbeta4 was knocked down by endothelial-specific expression of Tbeta4 short hairpin RNA. These data are in direct contrast to our published global and cardiac-specific Tbeta4-knockout lines. Thus, the role of Tbeta4 needs to be clarified to understand its importance in cardiovascular development. OBJECTIVE: To investigate and clarify the role of Tbeta4 in vascular smooth muscle cell development and vessel stability. METHODS AND RESULTS: Examination of Tbeta4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality. Endothelial-specific knockouts also did not exhibit any embryonic lethality and were viable to adulthood. CONCLUSIONS: Analysis of our Tbeta4 global and cardiac- and endothelial-specific knockout models demonstrated that Tbeta4 is dispensable for embryonic viability and vascular development. |
