| First Author | Haidey JN | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 5 | Pages | 109405 |
| PubMed ID | 34348138 | Mgi Jnum | J:311655 |
| Mgi Id | MGI:6764049 | Doi | 10.1016/j.celrep.2021.109405 |
| Citation | Haidey JN, et al. (2021) Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback. Cell Rep 36(5):109405 |
| abstractText | Very-low-frequency oscillations in microvascular diameter cause fluctuations in oxygen delivery that are important for fueling the brain and for functional imaging. However, little is known about how the brain regulates ongoing oscillations in cerebral blood flow. In mouse and rat cortical brain slice arterioles, we find that selectively enhancing tone is sufficient to recruit a TRPV4-mediated Ca(2+) elevation in adjacent astrocyte endfeet. This endfoot Ca(2+) signal triggers COX-1-mediated "feedback vasodilators" that limit the extent of evoked vasoconstriction, as well as constrain fictive vasomotion in slices. Astrocyte-Ptgs1 knockdown in vivo increases the power of arteriole oscillations across a broad range of very low frequencies (0.01-0.3 Hz), including ultra-slow vasomotion ( approximately 0.1 Hz). Conversely, clamping astrocyte Ca(2+)in vivo reduces the power of vasomotion. These data demonstrate bidirectional communication between arterioles and astrocyte endfeet to regulate oscillatory microvasculature activity. |
