| First Author | Hunsaker MR | Year | 2011 |
| Journal | Behav Brain Res | Volume | 222 |
| Issue | 1 | Pages | 117-21 |
| PubMed ID | 21440572 | Mgi Jnum | J:171685 |
| Mgi Id | MGI:4950791 | Doi | 10.1016/j.bbr.2011.03.039 |
| Citation | Hunsaker MR, et al. (2011) Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice. Behav Brain Res 222(1):117-21 |
| abstractText | The fragile X premutation is a tandem CGG trinucleotide repeat expansion on the FMR1 gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse with CGG trinucleotide repeat lengths between 70 and 350 has been developed and used to model the histopathology and cognitive deficits reported in carriers of the fragile X premutation. Previous studies have shown that CGG KI mice show progressive deficits in processing spatial and temporal information. To characterize the motor deficits associated with the fragile X premutation, male and female CGG KI mice ranging from 2 to 16 months of age with trinucleotide repeats ranging from 72 to 240 CGG in length were tested for their ability to perform a skilled ladder rung walking test. The results demonstrate that both male and female CGG KI mice showed a greater number of foot slips as a function of increased CGG repeat length, independent of the age of the animal or general activity level. |
