| First Author | Fung-Leung WP | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5253 | Pages | 1278-81 |
| PubMed ID | 8638109 | Mgi Jnum | J:31786 |
| Mgi Id | MGI:79272 | Doi | 10.1126/science.271.5253.1278 |
| Citation | Fung-Leung WP, et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science 271(5253):1278-81 |
| abstractText | HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4(+) T cells, which is indicative of positive selection in the thymus. Their CD4(+) cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells. |
