| First Author | Nishiyama H | Year | 2002 |
| Journal | Neurosci Lett | Volume | 321 |
| Issue | 1-2 | Pages | 49-52 |
| PubMed ID | 11872254 | Mgi Jnum | J:107965 |
| Mgi Id | MGI:3622600 | Doi | 10.1016/s0304-3940(01)02549-6 |
| Citation | Nishiyama H, et al. (2002) Normal development of serotonergic neurons in mice lacking S100B. Neurosci Lett 321(1-2):49-52 |
| abstractText | S100B, a glia-derived calcium binding protein, exhibits strong neurite extension activity in cultured serotonergic neurons. Using S100B-knockout mice, we examined whether this protein possesses in vivo serotonergic trophic activity. The distribution of serotonergic fibers, determined by immunohistochemistry, in the brains of S100B-knockout mice was quite similar to that of wild-type mice. Furthermore, the content of serotonin and its metabolite 5-hydroxyindole-3-acetic acid in knockout mice was also indistinguishable from those of wild-type mice. Our findings argue against the hypothesis that S100B has a crucial role in neurite extension of serotonergic neurons. |
