| Primary Identifier | MGI:2652473 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(APOA4)8018Feb |
| Strain of Origin | C57BL/6 x CBA | Is Recombinase | false |
| Is Wild Type | false |
| description | Nine copies of the transgene inserted into the genome. |
| molecularNote | The transgene construct comprises the human APOA4 gene with ~7 kb of 5'- and 6 kb of 3'- flanking genomic DNA. This transgenic line was estimated by densitrometric Southern blot analysis to carry ~9 copies of the construct. Human APOA4 protein was detected in plasma of these mice at ~11 times the level in human plasma. Like the endogenous transcript, transgene-derived human Apoa4 mRNA was present at significant levels in liver and at much higher levels in intestine. |
