| Primary Identifier | MGI:2450356 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(CD2-cre)1Tjw |
| Strain of Origin | (CBA x C57BL/6)F1 | Is Recombinase | true |
| Is Wild Type | false |
| description | Two transgenic founders displaying similar cre expression patterns were created. |
| molecularNote | The transgene consists of a modified cre recombinase gene fused to exon 1 of a human CD2 minigene just upstream of the translation initiation codon. The human CD2 promoter was used to drive transgene expression in T lymphocytes. The cre recombinase sequence was modified to include a nuclear localization signal and a modified KOZAK consensus sequence. Transgene expression was confirmed by immunohistochemical analysis of thymus and spleen from transgenic animals. |
