| First Author | Hamaguchi M | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31071011 | Mgi Jnum | J:274691 |
| Mgi Id | MGI:6304022 | Doi | 10.7554/eLife.41869 |
| Citation | Hamaguchi M, et al. (2019) Circulating transforming growth factor-beta1 facilitates remyelination in the adult central nervous system. Elife 8:e41869 |
| abstractText | Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-beta1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-beta type I receptor. Decrease in circulating TGF-beta1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-beta1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-beta1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-beta for demyelinating diseases. |
