| First Author | Kido M | Year | 1999 |
| Journal | FEBS Lett | Volume | 464 |
| Issue | 1-2 | Pages | 75-9 |
| PubMed ID | 10611487 | Mgi Jnum | J:59269 |
| Mgi Id | MGI:1351263 | Doi | 10.1016/s0014-5793(99)01681-6 |
| Citation | Kido M, et al. (1999) Normal levels of serum glycoproteins maintained in beta-1, 4-galactosyltransferase I-knockout mice. FEBS Lett 464(1-2):75-9 |
| abstractText | The galactose-mediated clearance of serum glycoproteins from the circulation was evaluated using beta-1,4-galactosyltransferase (beta-1,4-GalT) I-knockout mice. Partial structural study of the oligosaccharides released from mouse serum glycoproteins revealed that 77.4% of the oligosaccharides from beta-1,4-GalT I(+/+) mouse contain galactose, while 7.7% of those from beta-1,4-GalT I(-/-) mouse were galactosylated. Under the conditions, no significant change in serum protein concentrations was observed between the normal and mutant mice. The results indicate that the hepatic asialoglycoprotein receptor-mediated system is not functioning in the clearance of endogenous serum glycoproteins. |
