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Allele : Erbb2<tm1Vrtn> erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Timothy Vartanian

Primary Identifier  MGI:2651799 Allele Type  Targeted
Attribute String  Null/knockout Gene  Erbb2
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Sequence encompassing the exon encoding the essential transmembrane domain and portions of both the extracellular and cytomplasmic domains was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis detected reduced levels of protein in heterozygous embryos and no normal protein in homozygous embryos.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • erbB2<->,
  • erbB2<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele