| First Author | Lee EW | Year | 2003 |
| Journal | Peptides | Volume | 24 |
| Issue | 1 | Pages | 99-106 |
| PubMed ID | 12576090 | Mgi Jnum | J:102431 |
| Mgi Id | MGI:3607492 | Doi | 10.1016/s0196-9781(02)00281-4 |
| Citation | Lee EW, et al. (2003) Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice. Peptides 24(1):99-106 |
| abstractText | Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inhibited by Y2R- (and Y5R- but less by Y1R-) antagonists in wild type mice. Spontaneous and NPY-induced revascularization of ischemic gastrocnemius muscles were similarly reduced in Y2R-null mice. Thus, NPY-induced angiogenesis, spontaneous and ischemic, is primarily mediated by Y2Rs. However, Y5Rs and, to a lesser degree Y1Rs, also may play a role in NPY-mediated angiogenesis. |
