| First Author | Bouwknecht JA | Year | 2000 |
| Journal | Neuroreport | Volume | 11 |
| Issue | 18 | Pages | 4097-102 |
| PubMed ID | 11192635 | Mgi Jnum | J:103604 |
| Mgi Id | MGI:3610511 | Doi | 10.1097/00001756-200012180-00037 |
| Citation | Bouwknecht JA, et al. (2000) Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice. Neuroreport 11(18):4097-102 |
| abstractText | Relative to wildtype mice, mice lacking 5-HT1B receptors (5-HT1B KO) exhibit exaggerated heart rate and body temperature responses to environmental stimuli. In contrast, acoustic startle reactivity is reduced in 5-HT1B KO mice. We combined heart rate and temperature measurement with startle response paradigms in order to elucidate this apparent contradiction. Habituation and footshock-induced sensitization paradigms modulate startle reactivity. Reduced startle reactivity and unaltered habituation in 5-HT1B KO mice were replicated. Heart rate and temperature were unaffected by startle stimuli, but increased markedly in response to transportation and handling procedures. Footshocks caused a mild startle-sensitization and tachycardia in both genotypes. The physiological hyper-reactivity in 5-HT1B KO mice is a subtle phenotypic difference that contrasts with the phenotypic decrease in startle reactivity. |
