| First Author | Ramboz S | Year | 1996 |
| Journal | Behav Brain Res | Volume | 73 |
| Issue | 1-2 | Pages | 305-12 |
| PubMed ID | 8788525 | Mgi Jnum | J:113004 |
| Mgi Id | MGI:3664182 | Doi | 10.1016/0166-4328(96)00119-2 |
| Citation | Ramboz S, et al. (1996) 5-HT1B receptor knock out--behavioral consequences. Behav Brain Res 73(1-2):305-12 |
| abstractText | Serotonin is a neuromodulator that is involved in a number of mood disorders such as depression, anxiety and impulsive violence. In an attempt to dissect the contribution of individual 5-HT receptor subtypes to behavior, we have generated by homologous recombination, mutant mice lacking the 5-HT1B receptor. These mice did not exhibit any obvious developmental or behavioral defect. However, the hyperlocomotor effect of the 5-HT1A/1B agonist, RU 24969 was completely absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, isolated mutant mice attacked the intruder faster and more intensely than wild-type mice, suggesting an involvement of 5-HT1B receptors in the modulation of aggressive behavior. These data might be related to the fact that a class of 5-HT1 agonists, termed serenics, have anti-aggressive properties, and with the findings that certain impulsive aggressive behaviors are associated with deficits in central serotonin. |
