| First Author | Bouwknecht JA | Year | 2000 |
| Journal | Eur J Pharmacol | Volume | 403 |
| Issue | 1-2 | Pages | 95-8 |
| PubMed ID | 10969149 | Mgi Jnum | J:102602 |
| Mgi Id | MGI:3607824 | Doi | 10.1016/s0014-2999(00)00527-6 |
| Citation | Bouwknecht JA, et al. (2000) Ethanol intake is not elevated in male 5-HT(1B) receptor knockout mice. Eur J Pharmacol 403(1-2):95-8 |
| abstractText | Recently, the phenotype of increased ethanol intake in mice lacking 5-HT(1B) receptors could not be replicated. We assessed ethanol consumption in male wildtype and 5-HT(1B) receptor knockout mice derived from the original population. Intake of water and ethanol (0%, 3%, 6%, 10% and 20% v/v) from two pipettes was determined daily for 40 days. Ethanol intake (g/kg body weight) did not differ between genotypes, while body weights (20-25%) and water intake (50%) were elevated in 5-HT(1B) receptor knockout mice. Hence, the initial finding of elevated ethanol intake in 5-HT(1B) receptor knockout mice may have been due to phenotypic differences in fluid intake. |
