Primary Identifier | MGI:2653137 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Areg |
Inheritance Mode | Dominant | Strain of Origin | V/LeJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A T to G mutation occured in the G-GT splice donor site of exon 1 disrupting the donor site and resulting in the use of an alternative downstream splice site. The alternative splice site adds 22 nucleotides to the sequence resulting in a frame-shift and introducing a premature stop codon. Mcub is dominant modifier allele that causes a wavy coat in mice homozygous for the cub mutation. |