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Publication : Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.

First Author  Deponti D Year  2007
Journal  J Cell Biol Volume  179
Issue  2 Pages  305-19
PubMed ID  17954612 Mgi Jnum  J:135082
Mgi Id  MGI:3790354 Doi  10.1083/jcb.200701027
Citation  Deponti D, et al. (2007) Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation. J Cell Biol 179(2):305-19
abstractText  Regeneration of muscle fibers that are lost during pathological muscle degeneration or after injuries is sustained by the production of new myofibers. An important cell type involved in muscle regeneration is the satellite cell. Necdin is a protein expressed in satellite cell-derived myogenic precursors during perinatal growth. However, its function in myogenesis is not known. We compare transgenic mice that overexpress necdin in skeletal muscle with both wild-type and necdin null mice. After muscle injury the necdin null mice show a considerable defect in muscle healing, whereas mice that overexpress necdin show a substantial increase in myofiber regeneration. We also find that in muscle, necdin increases myogenin expression, accelerates differentiation, and counteracts myoblast apoptosis. Collectively, these data clarify the function and mechanism of necdin in skeletal muscle and show the importance of necdin in muscle regeneration.
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