| First Author | Zhang Y | Year | 2023 |
| Journal | Cell | Volume | 186 |
| Issue | 26 | Pages | 5751-5765.e16 |
| PubMed ID | 37989313 | Mgi Jnum | J:343324 |
| Mgi Id | MGI:7565199 | Doi | 10.1016/j.cell.2023.10.020 |
| Citation | Zhang Y, et al. (2023) Parallel neural pathways control sodium consumption and taste valence. Cell |
| abstractText | The hedonic value of salt fundamentally changes depending on the internal state. High concentrations of salt induce innate aversion under sated states, whereas such aversive stimuli transform into appetitive ones under sodium depletion. Neural mechanisms underlying this state-dependent salt valence switch are poorly understood. Using transcriptomics state-to-cell-type mapping and neural manipulations, we show that positive and negative valences of salt are controlled by anatomically distinct neural circuits in the mammalian brain. The hindbrain interoceptive circuit regulates sodium-specific appetitive drive , whereas behavioral tolerance of aversive salts is encoded by a dedicated class of neurons in the forebrain lamina terminalis (LT) expressing prostaglandin E2 (PGE2) receptor, Ptger3. We show that these LT neurons regulate salt tolerance by selectively modulating aversive taste sensitivity, partly through a PGE2-Ptger3 axis. These results reveal the bimodal regulation of appetitive and tolerance signals toward salt, which together dictate the amount of sodium consumption under different internal states. |
