| First Author | Schuster GU | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 348 |
| Issue | 1 | Pages | 176-82 |
| PubMed ID | 16876124 | Mgi Jnum | J:111953 |
| Mgi Id | MGI:3655195 | Doi | 10.1016/j.bbrc.2006.07.044 |
| Citation | Schuster GU, et al. (2006) Improved metabolic control by depletion of Liver X Receptors in mice. Biochem Biophys Res Commun 348(1):176-82 |
| abstractText | Liver X Receptors (LXRs) coordinate the regulation of lipid and carbohydrate metabolism and insulin signaling. LXR-ligands lower plasma glucose in hyperglycemic rodents and have consequently been proposed as anti-diabetic agents. We investigated the metabolic effects induced by high carbohydrate diet in LXRalpha(-/-)beta(-/-) mice. Irrespective of diets, LXRalpha(-/-)beta(-/-) mice had reduced fatty acid, insulin, and C-peptide plasma levels than wild-type controls, suggesting a lower insulin production. High carbohydrate diet decreased the plasma glucose levels and the homeostasis model assessment (HOMA)-index in LXRalpha(-/-)beta(-/-) mice and increased hepatic triglyceride content and mRNA levels of lipogenic genes in wild-type and LXRalpha(-/-)beta(-/-) mice, proportionally. In wild-type mice high carbohydrate diet was associated with induced expression of LXR (1.5-fold), despite unchanged SREBP-1c expression. LXRalpha(-/-)beta(-/-) mice responded to this diet by induction of SREBP-1c. Our study suggests that in LXRalpha(-/-)beta(-/-) mice, glucose utilization seems to be privileged possibly due to reduced circulating free fatty acid levels. |
