| First Author | Holm S | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 392 |
| Issue | 3 | Pages | 436-41 |
| PubMed ID | 20079709 | Mgi Jnum | J:157862 |
| Mgi Id | MGI:4437177 | Doi | 10.1016/j.bbrc.2010.01.042 |
| Citation | Holm S, et al. (2010) LXRbeta deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp. Biochem Biophys Res Commun 392(3):436-41 |
| abstractText | The present study addresses the insulin sensitivity in mice deficient in LXRbeta (LXRbeta(-/-)) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRbeta(-/-) mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRbeta(-/-) mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26weeks. |
