| First Author | Garofalo S | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 3103 |
| PubMed ID | 37248289 | Mgi Jnum | J:349226 |
| Mgi Id | MGI:7487451 | Doi | 10.1038/s41467-023-38899-3 |
| Citation | Garofalo S, et al. (2023) Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-gamma and acetylcholine. Nat Commun 14(1):3103 |
| abstractText | The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-gamma and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-gamma plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions. |
