| First Author | Ady V | Year | 2014 |
| Journal | EMBO Rep | Volume | 15 |
| Issue | 1 | Pages | 103-9 |
| PubMed ID | 24357660 | Mgi Jnum | J:211964 |
| Mgi Id | MGI:5577026 | Doi | 10.1002/embr.201337371 |
| Citation | Ady V, et al. (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors. EMBO Rep 15(1):103-9 |
| abstractText | The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity. |
