| First Author | Heit A | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 6 | Pages | 2802-5 |
| PubMed ID | 12626528 | Mgi Jnum | J:126272 |
| Mgi Id | MGI:3760935 | Doi | 10.4049/jimmunol.170.6.2802 |
| Citation | Heit A, et al. (2003) Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J Immunol 170(6):2802-5 |
| abstractText | Covalent linkage of immunostimulatory CpG DNA to OVA results in CpG DNA-aided cross-presentation of OVA by dendritic cells (DCs). In vivo, cross-presentation is conditional for cross-priming of OVA-specific CD8 T cells. In this study, we investigated the involvement of the CpG DNA receptor Toll-like receptor (TLR)9 in CpG DNA-aided cross-presentation and cross-priming. Although CpG DNA-aided cross-presentation is not altered in TLR9-deficient cells, TLR9 is required for maturation of APC allowing cross-priming, as resulting in CTL function. These findings imply that TLR9 does not trigger endocytosis of CpG-OVA conjugates, but activates DCs downstream of endocytosis. |
