| First Author | Koyama S | Year | 2010 |
| Journal | Sci Transl Med | Volume | 2 |
| Issue | 25 | Pages | 25ra24 |
| PubMed ID | 20424013 | Mgi Jnum | J:292406 |
| Mgi Id | MGI:6448930 | Doi | 10.1126/scitranslmed.3000759 |
| Citation | Koyama S, et al. (2010) Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med 2(25):25ra24 |
| abstractText | A variety of different vaccine types are available for H1N1 influenza A virus infections; however, their immunological mechanisms of action remain unclear. Here, we show that plasmacytoid dendritic cells (pDCs) and type I interferon (IFN)-mediated signaling delineate the immunogenicity of live attenuated virus, inactivated whole-virus (WV), and split-virus vaccines. Although Toll-like receptor 7 acted as the adjuvant receptor for the immunogenicity of both live virus and WV vaccines, the requirement for type I IFN production by pDCs for the immunogenicity of the vaccines was restricted to WV. A split vaccine commonly used in humans failed to immunize naive mice, but a pDC-activating adjuvant could restore immunogenicity. In blood from human adults, however, split vaccine alone could recall memory T cell responses, underscoring the importance of this adjuvant pathway for primary, but not secondary, vaccination. |
