| First Author | Kim JE | Year | 2003 |
| Journal | Neuron | Volume | 38 |
| Issue | 2 | Pages | 187-99 |
| PubMed ID | 12718854 | Mgi Jnum | J:83193 |
| Mgi Id | MGI:2658705 | Doi | 10.1016/s0896-6273(03)00147-8 |
| Citation | Kim JE, et al. (2003) Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38(2):187-99 |
| abstractText | After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in uninjured nogo-A/B(-/-) mice. After spinal cord injury, corticospinal axons of young adult nogo-A/B(-/-) mice sprout extensively rostral to a transection. Numerous fibers regenerate into distal cord segments of nogo-A/B(-/-) mice. Recovery of locomotor function is improved in these mice. Thus, Nogo-A plays a role in restricting axonal sprouting in the young adult CNS after injury. |
