| First Author | Wu Z | Year | 2014 |
| Journal | Nature | Volume | 509 |
| Issue | 7500 | Pages | 325-30 |
| PubMed ID | 24828191 | Mgi Jnum | J:210586 |
| Mgi Id | MGI:5571500 | Doi | 10.1038/nature13307 |
| Citation | Wu Z, et al. (2014) Galanin neurons in the medial preoptic area govern parental behaviour. Nature 509(7500):325-30 |
| abstractText | Mice display robust, stereotyped behaviours towards pups: virgin males typically attack pups, whereas virgin females and sexually experienced males and females display parental care. Here we show that virgin males genetically impaired in vomeronasal sensing do not attack pups and are parental. Furthermore, we uncover a subset of galanin-expressing neurons in the medial preoptic area (MPOA) that are specifically activated during male and female parenting, and a different subpopulation that is activated during mating. Genetic ablation of MPOA galanin neurons results in marked impairment of parental responses in males and females and affects male mating. Optogenetic activation of these neurons in virgin males suppresses inter-male and pup-directed aggression and induces pup grooming. Thus, MPOA galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses. These results provide an entry point to a circuit-level dissection of parental behaviour and its modulation by social experience. |
