| First Author | Rathinam C | Year | 2007 |
| Journal | PLoS One | Volume | 2 |
| Issue | 3 | Pages | e306 |
| PubMed ID | 17375192 | Mgi Jnum | J:129336 |
| Mgi Id | MGI:3769083 | Doi | 10.1371/journal.pone.0000306 |
| Citation | Rathinam C, et al. (2007) Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation. PLoS One 2(3):e306 |
| abstractText | Hematopoietic stem cell differentiation is specified by cytokines and transcription factors, but the mechanisms controlling instructive and permissive signalling networks are poorly understood. We provide evidence that CLP1-dependent IL7-receptor mediated B cell differentiation is critically controlled by the transcriptional repressor Gfi1. Gfi1-deficient progenitor B cells show global defects in IL7Ralpha-dependent signal cascades. Consequently, IL7-dependent trophic, proliferative and differentiation-inducing responses of progenitor B cells are perturbed. Gfi1 directly regulates expression levels of IL7Ralpha and indirectly controls STAT5 signalling via expression of SOCS3. Thus, Gfi1 selectively specifies IL7-dependent development of B cells from CLP1 progenitors, providing clues to the transcriptional networks integrating cytokine signals and lymphoid differentiation. |
