| First Author | Rana BMJ | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 9 | Pages | 1999-2009 |
| PubMed ID | 31248899 | Mgi Jnum | J:336874 |
| Mgi Id | MGI:6364382 | Doi | 10.1084/jem.20190689 |
| Citation | Rana BMJ, et al. (2019) A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med 216(9):1999-2009 |
| abstractText | Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT. |
