| First Author | Oshima S | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 5 | Pages | 1251-6 |
| PubMed ID | 16442103 | Mgi Jnum | J:106898 |
| Mgi Id | MGI:3619751 | Doi | 10.1016/j.febslet.2006.01.038 |
| Citation | Oshima S, et al. (2006) Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss. FEBS Lett 580(5):1251-6 |
| abstractText | A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1beta levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease. |
